NIVOLUMAB
Nivolumab belongs to a group of cancer drugs known as monoclonal antibodies. Nivolumab is also known as an immune checkpoint inhibitor. Sometimes these drugs are called targeted therapies because they target specific proteins (receptors) on the surface of cells. Nivolumab is a prescription drug which is used under the supervision of a doctorINDICATION
Nivolumab is indicated for the treatment of patients having Melanoma. Nivolumab is indicated for the treatment of patients having Non-Small Cell Lung Cancer. Nivolumab is indicated for the treatment of patients having Kidney (Renal Cell) Cancer.MECHANISM OF ACTION
Nivolumab prohibits the molecule activity called PD-1, and it is a protein which prevents T cells from recognizing and attacking inflamed tissues and cancer cells. PD-1 can deceit the immune system into overlooking melanoma cells as normal cells.DOSAGE AND ADMINISTRATION
Nivolumab recommended dosage for unresectable or metastatic melanoma :As a single agent is either 240mg every 2 weeks or 480mg every 4 weeks given as IV infusion over 30 minutes until disease progression or unacceptable toxicity
With ipilimumab. The recommended dose of Nivolumab is 1mg/kg administrated as an intravenous infusion over 30 minutes, followed by ipilimumab 3mg/kg given as IV over 90 minutes on the same day. Duration 3 weeks of max 4 doses, after completing combination does continue the single agent treatment.
COMMON SIDE EFFECTS
FatigueLymphocytopenia (Low White Blood Cells)
Low Sodium
Shortness of breath
Musculoskeletal Pain
Decreased Appetite
Cough
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